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King WC, Chen J-Y, Courcoulas AP, et al

In the Phase 2 clinical trial (NEJM, 2023), retatrutide was administered subcutaneously at doses ranging from approximately 0.5 mg to 12 mg per week, with dose escalation under close medical supervision

To prevent the spontaneous Fab arm exchange that IgG4 Abs undergo in vivo , rozanolixizumab harbors a S241P amino acid substitution in its hinge region that stabilizes the connection between the two HCs [124, 257]