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A synthetic pentadecapeptide (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val), BPC-157 was first isolated from human gastric juice by Predrag Sikiric and Sven Seiwerth at the University of Zagreb School of Medicine in the early 1990s.3 Sikirics laboratory has since published more than 200 studies on the compoundan extraordinary body of work that has attracted both admiration for its breadth and criticism for originating almost entirely from a single research group

Sikiric and colleagues have proposed nitric oxide system involvement, while other groups have documented effects on VEGF receptor 2 expression, growth-hormone receptor upregulation, and dopamine pathway modulation

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