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70 As a result, STAT3-dependent ZIP6 expression leads to downstream activation of the transcriptional repressor Snail, which contributes to the epithelial-mesenchymal transition (EMT) during embryonic development and is associated with tumor metastasis mechanisms (Fig
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In addition, research has recently shown that the anticancer effects of vitamin E are due to the - and -tocopherol forms and is not associated with -tocopherol
Although these methods have proven clinical efficacy, they fail to directly target the central pathophysiologic mechanisms at play in heart failure
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