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Exenatide, a synthetic version of exendin-4 produced industrially, was the first GLP-1RA approved for the market [exenatide twice daily (EX-BID)], followed by a long-acting formulation that improved the delivery system [exenatide once a week (EX-QW)]

This creates a cascade of metabolic dysfunction that makes traditional weight management approaches less effective during perimenopause.[2] GLP-1 Receptor Agonists: Mechanisms of Action in Perimenopause GLP-1 receptor agonists work through multiple pathways that are particularly relevant to perimenopausal women: Appetite Regulation and Satiety These medications reduce appetite and food cravings by activating satiety centers in the brain and slowing gastric emptying

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Xu Y, Tu W, Sun D, Chen X, Ge Y, Yao S, et al