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The mild injection site reactions that represent the most common side effect pale in comparison to the nausea, constipation, and digestive upheaval that accompanies GLP-1 therapy

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Properly stored with bacteriostatic water, most peptides maintain stability for 28-30 days

Typical Post-Injection Timeline First 24-48 hours: Mild to moderate pain at the injection site Localized warmth and redness Slight swelling around the knee Temporary stiffness or reduced range of motion Days 2-3: Gradual reduction in swelling Decreased pain and tenderness Return to normal mobility Possible spongy sensation when walking [4] The American Academy of Orthopaedic Surgeons notes that patients should avoid excessive activity, such as jogging or heavy lifting for the first 48 hours after injection [2]