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So, even though these two defenses against oxidative stress do not exhibit any significant downregulatory malfunction, a lack of their upregulation during a period of increased oxidative stress can contribute to the enhanced ROS experienced by the MUN placenta by not effectively removing enough superoxide and hydrogen peroxide from the placental environment

10.1158/0008-5472.CAN-14-3080 41 LiuC.YangJ

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