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Layla Abushamat, assistant professor of medicine at Baylor College of Medicine

Various factors are involved in the progression of DN, such as disorder of oxygen metabolism and lipid metabolism, hyperglycemia, advanced glycosylation products, and inflammatory response [140, 141]

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These pathways activate SYK and PI3K, which in turn promote phagocytosis, proliferation, and microglial survival [448, 449]