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Structural modifications to IGF-1 LR3specifically the inclusion of additional amino acids at the N-terminus and a substitution at position threehave been associated with enhanced receptor affinity

doi: 10.1016/j.arbres.2016.09.003 34 PhillipsCMac ParthalinNSyedYDeganelloDClaypoleTLewisK

The magnitude of these differences suggests that the benefits of dual agonism extend beyond simple additive effects

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