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LMet restriction with orMETase used as a supplement every 6 h for six months and a low-LMet diet, showed synergistic efficacy with neoadjuvant doxorubicin and cyclophosphamide administration for the first 3 months, followed by docetaxel for the next 3 months, leading to a remarkable response that is typically expected in fewer than 10% of patients with invasive lobular carcinoma (breast cancer) treated with neoadjuvant chemotherapy alone

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