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The SURMOUNT-1 Phase 3 trial published in the New England Journal of Medicine demonstrated 20.9% mean body weight reduction at 72 weeks on tirzepatide 15mg weekly versus 3.1% with placebo

Patients with pre-existing cardiovascular conditions, uncontrolled hypertension, or structural cardiac abnormalities require particularly cautious evaluation, and stimulants may be contraindicated in certain high-risk individuals

5 Figure 2: Diabetes Drug Market Overview by Segment, 20212031

Patients with specific genetic profiles can start lower, escalate slower, or choose alternative compounds known to cause fewer problems based on their genetic architecture