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Reduction in Body Fat GLP-1 medications have been associated with reductions in visceral adipose tissue (fat stored around internal organs), which is particularly beneficial for metabolic health
The primary function of the HSD11B1 encoded enzyme is to reduce the 11-oxo groups in cortisone and 11-dehydrocorticosterone to the active glucocorticoids, cortisol and corticosterone, respectively
Stopping GLP-1 therapy typically leads to weight regain (50-70% within 12 months) and worsening glycaemic control in diabetes patients
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