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FOXO4-DRI works by disrupting the interaction between the FOXO4 protein and p53, enabling p53 to activate apoptosis in senescent cells

doi: 10.1189/jlb.1009655 122 ZhangPXMurrayTSVillellaVRFerrariEEspositoSDSouzaAet al

Rapamycin-induced autophagy ameliorates GSH depletion-induced premature cell senescence It was shown that autophagy activation especially in the presence of an increasing autophagic flux inhibits the senescence of RPE cells 35,36,37,38,39