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Transmembrane glycoprotein mucin 1 (MUC1) also exhibits Nrf2 regulation, specifically through dimerisation of its transmembrane and cytoplasmic domain (MUC1-C), which represses Keap1 expression while promoting phosphorylation of glycogen synthase kinase 3 (GSK3)

4% paraformaldehyde-fixed brains were embedded in paraffin, and 4 m-thick sections were mounted onto MAS-GP-coated glass slides (Matsunami-glass, Osaka, Japan)

This multi-receptor approach is particularly promising, as it may offer a more comprehensive solution compared to traditional weight loss medications that typically focus on a single pathway

Serum was obtained by centrifuging blood samples at 10,000 g for 5 min and stored at 80 C