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However, there are still many open questions, and several factors have to be considered in the interpretation of this transduction model: (1) functional studies are still very limited and mainly conducted in recombinant systems, (2) gustducin-knockout mice showed residual sweet taste responses, (3) besides G gust , also other G q and G i subunits have been found in taste bud cells (Table 3), (4) several second messengers are mobilized by sweet taste receptor activation

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Kennedy argued that the activities were unnecessary, and that the Navy had illegally destroyed several endangered species, polluted the island's waters, harmed the residents' health, and damaged its economy