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Neither should be used with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping one, as doing so can increase the risk of dangerously high blood pressure and serotonin syndrome

For a deeper look at the mechanism behind these medications, see how GLP-1 works for weight loss

In the light of subsequent incidences of serious idiosyncratic liver toxicity associated with this product whilst on the market, it would seem that when there are differences in the incidence of liver enzyme elevation between active- and placebo-treated groups in clinical trials, this should be considered a signal to examine the clinical and non-clinical data very closely before licensing

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