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2.4 Other Diseases Oxidative damage caused by overactivation of the immune response is the key pathogenic factor of chronic inflammation conditions, such as Crohns disease (CD), rheumatoid arthritis, and the inflammatory bowel diseases (Shimizu et al., 2015), but whether this protective mechanism is related to gut microbiota has not been studied

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The risk of bias in randomized controlled studies was assessed using the Cochrane Risk of Bias (RoB2) tool, while the ROBINS-I tool was employed for non-randomized studies included in this review