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Tsuji-Naito et al 27 demonstrated that DHLHZn (sodium zinc dihydrolipoyl histidinate, compound of Zn2+/dyhydrolipoic acid derivative complex, which was developed for cosmetic/medical use) serves as a potentially effective skin-lightening agent, an effectiveness that is based on the compounds covalent scavenging of DOPAquinone, resulting in depigmentation

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Typically, extracellular Fe + is sequestered by transferrin, then reduced to Fe + within the cell, with any surplus exported by SLC40A1 ( + is usually sequestered in ferritin

This dose, however, comes with serious side effects including anxiety, irritability, palpitations, acne, rash, sore muscles, achy joints, insomnia, nausea, headaches, and migraines