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[14] When taken orally, L-Carnitine requires a high dose to promote fat tissue breakdown

While major regulatory bodies like the FDA and EFSA deem it safe for the general public, the IARC has classified it as "possibly carcinogenic to humans" (Group 2B)

Its tri-agonist receptor activity supports research into receptor pharmacology, endocrine pathway regulation, lipid metabolism, hepatic signaling, and cross-tissue metabolic communication in controlled laboratory and translational research environments [1][5]