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Intestinal barrier dysfunction leads to the translocation of gut bacteria and endotoxins (Lipopolysaccharide, LPS) into the bloodstream, which specifically activate Kupffer cells (KCs) in the liver of both heatstroke patients and mouse models

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For example, tryptase is a proteolytic enzyme and can break down nerve endings

1C) with a measured interfringe distance of 0.24 nm, which is consistent with lattice spacing of the face centered cubic (111) gold (Fig