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The S-protein binds host receptor angiotensin converting enzyme 2 (ACE2) and mediates viral entry into the host cell, similar to 2002 SARS-CoV 3

305 At the therapeutic level, therapeutic vaccines targeting Arg 1 have been shown to activate antitumor immunity in a variety of syngeneic mouse tumor models such as lung cancer, melanoma, and colon cancer, and the combination of Arg 1 vaccine with anti-PD-1 antibody can increase T cell infiltration, inhibit myeloid cell function, and increase the ratio of tumor-infiltrating M1/M2 macrophages

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Generative AI statement The author(s) declared that generative AI was not used in the creation of this manuscript