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M1 macrophages play a key role in the initial stages of the inflammatory response by releasing considerable amounts of inflammatory agents such as tumor necrosis factor (TNF-), IL-6 and IL-12, which contribute to aggravating inflammation

(TNF-), interleukin (IL)-1, IL-6, IL-8, IL-10, IL-12, and interferon- (IFN) are produced by thyroid follicular cells and intra-thyroidal inflammatory cells

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