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PLGA NPs have demonstrated minimal cytotoxic effects at concentrations up to 100 g/ml in both neuronal and glial cell cultures, and in vivo studies suggest lower accumulation in brain tissue and faster systemic clearance compared to metallic analogues [180]

This shift aligns with the growing consensus that managing diabetes requires more than glycemic control

Side effects are generally mild and may include headaches, flushing, or temporary irritation at the injection site

Given that peanut allergy can cause life-threatening anaphylaxis, a peptide-based approach that achieves tolerance without risking severe reactions represents a genuine breakthrough