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Researchers planning protocols are referred to the original primary literature cited in the References section for full methodological detail, including vehicle composition (the Sun 2021 vehicle was 10% DMSO, 40% PEG300, 5% Tween-80, 45% saline), administration timing relative to behavioral testing, and outcome assessment timepoints

In this regard, the intranasal route is a promising delivery method to obtain greater efficacy in maintaining optimal drug concentrations in the brain compared to parenteral injections (Mittal et al., 2013

Both the ADA and ACP emphasize medical nutrition therapy, physical activity, and behavioral support as cornerstones of diabetes and weight management

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