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For example, NMR-titration experiments of non-glutathionylated poplar GrxC4 or ScGrx8 with GSH required high glutathione concentrations to detect chemical shifts 47,48 (and titrations of active site serine mutants with GSSG cannot discriminate between both glutathionyl moieties)

TNF- antagonists or TNFR knockdown suppress c-Jun N-terminal kinase (JNK) phosphorylation and alleviate BTZ-induced mechanical hypersensitivity (Zhang et al., 2014)

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Further, pre-administration of ebselen in the mice model provided significant improvement in the 30-day survival against radiation-induced mortality