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J Neurosci (2011) 31:390413

The Saito group [146] employed high-fat diet-induced obese mice and genetically obese ob/ob mice as experimental models and found that malonyl-CoA levels were elevated in obese tissues, where malonyl-CoA binds to the Rossmann fold domain of C-terminal binding protein 2 (CtBP2), facilitating the interaction between CtBP2 and PPAR

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