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I think theres a lot of research to make the decision. The image on this page, obtained from Wikimedia Commons, is being used under a Creative Commons license

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When binding a ligand, the receptor is activated to translocate into nuclei and, during the nuclear translocation process, dissociates from the 90 kDa heat shock protein (Hsp90) to form a heterodimer with Arnt (Ah receptor nuclear translocator)

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