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Taken together with the findings that utilization of esketamine as an antidepressant increases LAC levels [59], the fact that the decrease in LAC levels in subjects with MDD is independent of psychotropic drug treatment raises the possibility that increasing LAC levels may be needed to induce antidepressant effects

The tradeoff is that patients need to be prepared for dose escalation, possible side effects, and the importance of hydration, protein intake, bowel regularity, and consistent follow-up

Experts note that the absence of diabetes among participants and the strict use of GLP-1s for weight loss is a critical caveat, as diabetes is a substantial risk factor for AMD

However, some women have reported changes to their cycle during treatment