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Orforglipron, if successful, could broaden access and sharpen competition in one of pharmas hottest markets, pressure already visible as Novo announced 9,000 job cuts amid intensifying rivalry

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Co-activation of both systems could mitigate GLP-1 drawbacks while having an additive effect on weight loss, allowing for lower doses of each therapy

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However, this pathway carries both opportunities and substantial risks that must be carefully navigated

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It interferes with the natural form of L-carnitine in relation to intestinal absorption and reversing resorption in the kidneys

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