Tirzepatide is given subcutaneously once a week and was examined in four worldwide phase III randomized, placebo-controlled clinical trials as part of the SURMOUNT Program, which also includes lifestyle modification
Urine samples collected for the measurement of F 2 -IsoPs were stored at 80C prior to shipment to Vanderbilt Eicosanoid Core Laboratory (Nashville, Tennessee, USA) for quantification of F 2 -IsoPs F 2 (PGF 2 ), free 8-iso-prostaglandin F 2 (8-iso-PGF 2 ), 2,3-dinor-5,6-dihydro-15-F 2t -IsoP and 5-series F 2 -IsoP by GC-negative ion chemical ionisation-MS employing stable isotope dilution as described in Milne et al
Finally, we found that tirzepatide consistently increased somatostatin secretion (Fig
In the meantime, documenting patient baseline characteristics and outcomes by surgeons in the United States will be important to understand the benefits of liposuction for lipedema in the US population compared to reports from other countries (e.g., Germany)
