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For these reasons, I respectfully urge the Agency to incorporate illicit-market substitution effects into its evaluation of MRTP applications and to weigh whether timely authorization of qualifying products accompanied by appropriate post-market oversight may better advance the statutory goal of improving population health than continued regulatory limbo

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Journals of international repute, such as the Times, the Daily Telegraph, the Neue Freie Presse, the Journal des Dbats, sold fewer copies in a week than the popular organs now dispose of in a day