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Studies revealed that the expression of genes related to glutathione metabolism, mitochondrial transport, pyruvate metabolism, the TCA cycle, ETC were altered in smokers and COPD patients (37)

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They act on the 3'-untranslated regions (UTRs) of mRNAs to regulate the stability and translation of mRNAs encoding target proteins, and negatively regulate gene expression at the post-transcriptional level [18]

A comprehensive examination of hookah smoking in college students: use patterns and contexts, social norms and attitudes, harm perception, psychological correlates and co-occurring substance use