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GLP-1 receptor agonists do not generally cause hypoglycemia, but it is recommendable to decrease the dose of concomitant sulphonylurea or insulin to reduce the risk of hypoglycemic episodes

In the pivotal STEP 1 clinical trial, participants who received weekly semaglutide injections lost an average of 14.9% of their body weight over 68 weeks , compared with 2.4% in the placebo group (study in the New England Journal of Medicine )

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60% of participants achieved 20% or more weight loss -- a threshold historically associated with bariatric surgery outcomes