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HRT Addresses: Estrogen-driven fat redistribution, muscle loss prevention, sleep disruption, hot flashes and night sweats GLP-1 Addresses: Appetite dysregulation, insulin resistance, blood sugar instability, inflammation reduction Combined Benefit: Targets both hormonal AND behavioral factors, which can help preserve lean mass while losing fat and support better energy for lifestyle changes, leading to comprehensive quality of life improvement Rather than competing approaches, hormone optimization therapy and GLP-1 therapy can work through distinct physiological pathways that reinforce each other

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Acknowledgements This work is supported by the National Natural Science Foundation of China (22172008, L.F

Unlike other administration methods, the TF model overcomes the innate aversion to alcohol often observed in rodents, ensuring better control over the alcohol intake of each experimental animal and reducing experimental errors