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Finally, we found a similar decrease in survival when treating CCNE1-driven cells with PARP inhibitors that have less PARP-trapping activity than olaparib (Extended Data Fig

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doi:10.1007/s40265-014-0230-8 94

Together, these results suggest that SLC25A45 deletion leads to a shift in fuel choice toward carbohydrates/glucose catabolism due to a reduced systemic carnitine pool and impaired long-chain fatty acid oxidation, while SLC25A45 KO mitochondria could utilize alternative fuels, such as pyruvate and medium-chain fatty acids