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This review discussed the significant effect that E-cig use had on the BC tumor microenvironment, which ultimately led to enhanced tumor malignancy and metastasis, with an emphasis on the extent that E-cig uses had on the crosstalk between cancer and immune cells, as well as the potential underlying mechanisms that drive this aggressive phenotype of BC

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[14] Elizabeth Dodds, Marriage to a Difficult Man: The Uncommon Union of Jonathan and Sarah Edwards (reissued Audubon Press, 2004), 4041