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Among the 21 global regions, South Asia had significantly higher ASDR and ASDALYR in 2021, which was 6232 greater than other global regions (Supplementary Table S5

For example, Wakefield and colleagues found that plain packaging was significantly more effective in reducing brand appeal than increasing the size of the public health warning, and that plain packaging lowered intentions to buy cigarettes [15]

(We refer readers to section IV.A.4.c.(3) of this proposed rule for further discussion regarding the APP Plus quality measure set.) Aligning the APP Plus quality measure set with the Adult Universal Foundation measure set serves to advance Medicare's overall value-based care strategy and maintain alignment within and across CMS's quality programs