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Functional brain imaging studies in healthy (mostly male) volunteers showed that CBD (600 mg) attenuated the blood oxygenation signal in the amygdala and the anterior and posterior cingulate cortex while subjects ( n = 15) were processing intensely fearful faces [59] and reduced prefrontal-subcortical neural connectivity when shown fearful faces ( n = 15) [46], brain region imaging findings that could be translated into anxiolytic effects