Collins tambin ofreci algunas posibles explicaciones de por qu ocurre esto
Sugio, S., Kashima, A., Mochizuki, S., Noda, M
The endoplasmic reticulum (ER) is the site of protein production and relies heavily on Ca 2+ concentrations to maintain the environment needed for proper protein synthesis and folding ( Figure 2A ) ( Figure 2F ) ( via the glucose transporter 2 (Glut2) in rodents (GLUT1 and 3 in humans), converted to pyruvate, and shuttled into the mitochondria where it is used for ATP production ( 2+ influx, and insulin release ( Insulin mRNA is translated at the ER following nutrient stimulation, which in rodents can signal up to a 10-fold increase in insulin synthesis at a rate of 1 million molecules per minute ( Figure 2 To meet these high demands, beta-cells have an extensive ER with multiple chaperones to aid in protein folding, packaging, and secretion

HHV6 can cause dysregulation of glutamate transport in neural astrocytes with the potential for similar effects on the peripheral sensory neurons in the DRG : Human herpesvirus 6 (HHV-6) induces dysregulation of glutamate uptake and transporter expression in astrocytes