semaglutide nature medicine Bimagrumab plus alone or in combination for the treatment of obesity: a randomized phase 2 trial Oral GLP-1 Medication Helps Patients

Research-design considerations Designs using Retatrutide benefit from accounting for its extended half-life in study time-courses, allowing multi-week durations for steady state, including endpoints relevant to all three receptor systems, and for comparative work including single- or dual-agonist reference compounds

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References Sosne G, Qiu P, Kurpakus-Wheater M

Studies involving acoustic and chemical insults show that growth factors represent a compelling class of otoprotective compounds (Yagi et al., The HGF mimetic Dihexa is a synthetically derived Angiotensin IV analog that is blood-brain barrier permeable, stable, and orally bioavailable (McCoy et al., in vitro and in vivo , making a strong case for a small molecule activator of HGF/c-Met to confer a neuroprotective benefit (Zhang et al., The experimental value of zebrafish as an animal model for in vivo drug discovery has grown rapidly due to their ease of assessment, large clutch size, and ability to recapitulate human disease conditions (MacRae and Peterson, in vivo , demonstrating that otoprotective drug discovery in zebrafish translates to mammalian systems (Owens et al., In this study, we demonstrate that Dihexa protects lateral line hair cells from aminoglycoside ototoxicity