17 Insomnia can potentially be addressed by taking the first dose early in the morning and the second in the late afternoon (at least four hours before bedtime), or by reducing total daily intake to 150 mg
15 Patients usually begin one to two weeks before their quit date, with a one week dose escalation period, followed by 11 weeks of maintenance treatment:* 15 Step 1 set a quit date Step 2 initiate varenicline one to two weeks before this quit date, initially at a dose of 500 micrograms, once daily, for the first three days Step 3 increase the dose to 500 micrograms, twice daily, for four days Step 4 increase the dose to 1 mg, twice daily Step 5 most patients should continue with this maintenance dose for 11 weeks
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