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doi: 10.2337/dc12-1925 26 FriedrichsenMBreitschaftATadayonSWizertASkovgaardD
Conclusion While the idea of splitting semaglutide doses to twice a week may seem appealing, it's essential to approach any changes to your medication regimen with caution and under professional guidance
The bottom line The old quote: "Let food be thy medicine" is catchy and often based on science, especially when drugs are deliberately chosen or designed to mimic hormones and compounds already naturally occurring in the body
Researchers who have studied it understand the core mechanism: GLP-1 receptor (GLP-1R) agonism produces glucose-dependent insulin secretion from pancreatic beta cells, suppresses glucagon release from alpha cells, slows gastric emptying, and engages hypothalamic appetite circuits specifically the arcuate nucleus to reduce caloric intake through neuropeptide Y/AgRP suppression and POMC/CART activation
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