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GLP-1 receptor agonists slow gastric emptying, causing constipation in approximately 24% of patients taking higher doses such as semaglutide 2.4mg

Despite the effectiveness of current treatments for weight management, some individuals will not reach the therapeutic goals that are associated with greater body weight reduction, Sean Wharton, MD, FRCPC, PharmD, medical director of the Wharton Medical Clinic, assistant professor at the University of Toronto and adjunct professor at both McMaster University in Hamilton, Ontario, and York University in Toronto, and colleagues wrote in the STEP UP publication

Sick day management : Jardiance should be temporarily stopped during periods of acute illness with dehydration or reduced food/fluid intake, and usually 3 days before major surgery, to reduce diabetic ketoacidosis risk

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