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This market-cap-weighted index consists of 400 companies that have met rigorous standards of environmental excellence and social responsibility, contribute to the local communities in which they are located, produce high-quality and safe products, enrich the ecosystem on which they depend, invest in the health and development of their employees, and treat their investors and lenders openly and transparently.(Domini.com, Social Investment Standards) Of the 400 companies in this index, 250 are directly from the S&P 500 Companies dealing with alcohol, gambling, weapons, nuclear power, and tobacco are not allowed in the DSI 400

38 Xiong et al

Semaglutide treatments can be expensive, particularly in low- and middle-income countries where insurance coverage remains limited

Adjusting the timing of doses or selecting alternative treatments may be necessary for optimal therapeutic results