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There are contradicting results from other studies claimed that a chow diet plus 1% or 5% butyrate did not significantly affect body weight in mice (50, 61) and even that offspring rats of mothers fed a 1% butyrate in a chow diet had higher body weight (62)

Many preclinical studies have demonstrated that the expression of key enzymes for GSH synthesis (GCL, SLC7A11, GS) and GSSG reduction-related enzymes (G6PD, NADPH, and GR) is downregulated in myocardium exposed to pathological factors [40, 43,44,45,46,47,48,49,50]

Thoudam T, Chanda D, Lee J, Jung M, Sinam I, Kim B, Park B, Kwon W, Kim H, Kim M (2023) Enhanced Ca2+-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease

La L-Carnitina si dimostrata essere terapeuticamente efficace nelle seguenti patologie: a) deficit primari di Carnitina caratterizzati da fenotipi quali miopatie con accumulo lipidico, encefalopatia epatica tipo sindrome di Reys e/o cardiomiopatia dilatativa progressiva