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To explore the potential mechanisms involved in cigarette smoke-induced resistance to EGFR TKI, gene set enrichment analysis (GSEA) was performed to profile CSE-related gene expression in 1094 patients with NSCLC, which did not include the EGFR status using the published gene sets [20,21,22,23,24,25]

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Vaping devices and e-cigarettes may also contain THC, the active ingredient in marijuana, and potentially unsafe levels of chemicals like lead, manganese, chromium, and/or nickel