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Recurrent tobacco use resulting in a failure to fulfill major role obligations at work, school, or home (e.g interference with work) Continued tobacco use despite having persistent or recurrent social and interpersonal problems caused or exacerbated by the effects of tobacco (e.g arguments with others about tobacco use) Important social, occupational, or recreational activities are given up or reduced because of tobacco use

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Some smoke detectors may continue to chirp after you replace the batteries

The substance is a weak base with a pKa of 8, meaning at pHs greater than 8 it is unprotonated, also called freebase nicotine