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EV-mediated cargo transfer to recipient cells affects many stages of cancer progression through communication between the cancer cells and the surrounding tumor microenvironment, such as the promotion of myofibroblast differentiation 33 , activation of proliferative and angiogenic pathways 34 , and initiation of pre-metastatic sites 35,36

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Based on smuggled cigarettes consumed as a percentage of total cigarettes consumed in 2013, these are the states with the highest cigarette smuggling rates