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Constructed by: Tracy Gray Edited by: Will Shortz Todays Reveal Answer: One-Up Themed clues are all in the across-direction, and use the letters ONE written in the up-direction in the grid: 69A Outdo or a hint to entering four answers in this puzzle : ONE-UP 18A Strategy used in basketball and football : Z ONE DEFENSE 33A Exclamation of surprise : HOW ON E ARTH

These results show that senescence of lung epithelial cells is likely related to the development of COPD/emphysema and that, during the induction of COPD/emphysema, smoking elevates senescence-related indicators and miR-125a-5p levels in lung tissue

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