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Within the barrel-stave model, the aNDB molecules are initially oriented parallel to the membrane but eventually inserted perpendicularly in the lipid bilayer (Hegde et al., 2022) (Figure 4)

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Disturbances in GSH homeostasis have been implicated in neurodegenerative disorders, liver disease, cystic fibrosis, pulmonary and cardiovascular diseases, as well as the chronic age-related diseases and the aging process itself.Recent data also suggests it plays a role in metabolic and inflammatory diseases such as multiple sclerosis, the metabolic syndrome, and diabetes, at least in part by influencing the effect of multiple environmental toxins, an underappreciated yet surprisingly significant association