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Mallach et al., 2024), tauopathy (Busche and Hyman, 2020), gliosis, neural atrophy and death (De Strooper and Karran, 2016), lysosomal dysfunction (Nixon and Rubinsztein, 2024), acidification and Ca 2+ dyshomeostasis (LaFerla, 2002), and vasculature damage and angiopathy (Zlokovic, 2011) have been investigated long time

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